Abstract
Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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B-Lymphocytes / metabolism
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Cell Separation
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Chromosomes / ultrastructure
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Cytidine Deaminase / genetics*
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Cytidine Deaminase / metabolism
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Cytidine Deaminase / physiology*
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Enzyme-Linked Immunosorbent Assay
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Flow Cytometry
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Immunoglobulin G / chemistry
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Immunoglobulins / chemistry
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Interleukin-6 / metabolism
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Mice
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Mice, Inbred BALB C
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Mice, Transgenic
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Models, Genetic
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Polymerase Chain Reaction
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Protein Transport
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Proto-Oncogene Proteins c-myc / metabolism*
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Time Factors
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Translocation, Genetic*
Substances
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Immunoglobulin G
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Immunoglobulins
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Interleukin-6
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Proto-Oncogene Proteins c-myc
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AICDA (activation-induced cytidine deaminase)
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Cytidine Deaminase