Abstract
Proteomics is an increasingly powerful and indispensable technology in molecular cell biology. It can be used to identify the components of small protein complexes and large organelles, to determine post-translational modifications and in sophisticated functional screens. The key - but little understood - technology in mass-spectrometry-based proteomics is peptide sequencing, which we describe and review here in an easily accessible format.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Computational Biology
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Databases, Factual
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Mass Spectrometry / instrumentation
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Mass Spectrometry / methods
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Molecular Structure
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Peptides* / analysis
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Peptides* / genetics
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Protein Isoforms / analysis
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Protein Isoforms / genetics
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Proteomics / methods*
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Sequence Analysis, Protein / instrumentation
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Sequence Analysis, Protein / methods*
Substances
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Peptides
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Protein Isoforms