Abstract
Mitochondria exist as an interconnected network that is constantly remodeled by balancing membrane fission and fusion events. A new study by Szabadkai et al. in the October 8th issue of Molecular Cell shows that dynamin-related protein 1 (Drp1)-induced scission hinders the ability of mitochondria to transport calcium across the cell and mediate apoptosis.
MeSH terms
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Apoptosis Regulatory Proteins
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Apoptosis*
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Calcium / metabolism
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Calcium-Calmodulin-Dependent Protein Kinases
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Cell Membrane / metabolism
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Death-Associated Protein Kinases
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Endoplasmic Reticulum / metabolism
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HeLa Cells
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Humans
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Image Processing, Computer-Assisted
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Imaging, Three-Dimensional
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Microscopy, Fluorescence
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Mitochondria / metabolism*
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Protein Serine-Threonine Kinases / metabolism
Substances
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Apoptosis Regulatory Proteins
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Death-Associated Protein Kinases
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Protein Serine-Threonine Kinases
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Calcium-Calmodulin-Dependent Protein Kinases
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Calcium