Abstract
The pRb/E2F and Wnt/beta-catenin pathways are two of the most frequently deregulated pathways in human cancers. In this study, we show that E2F1 up-regulates the expression of axin2. Further, we show that axin2 can repress Wnt signalling leading to reduced cell growth and increased cell death. This represents cross-talk between major pathways involved in the formation of tumours. We use our data to suggest a novel mechanism for tumour suppression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Cycle Proteins / metabolism*
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Cell Death / physiology*
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Cells, Cultured
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Cloning, Molecular
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Cytoskeletal Proteins / metabolism*
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DNA-Binding Proteins / metabolism*
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E2F Transcription Factors
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E2F1 Transcription Factor
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Intercellular Signaling Peptides and Proteins / metabolism*
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Rats
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Retinoblastoma Protein / metabolism*
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Signal Transduction / physiology
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Trans-Activators / metabolism*
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Transcription Factors / metabolism*
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Wnt Proteins
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beta Catenin
Substances
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Cell Cycle Proteins
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Ctnnb1 protein, rat
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Cytoskeletal Proteins
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DNA-Binding Proteins
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E2F Transcription Factors
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E2F1 Transcription Factor
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E2f1 protein, rat
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Intercellular Signaling Peptides and Proteins
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Retinoblastoma Protein
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Trans-Activators
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Transcription Factors
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Wnt Proteins
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beta Catenin