Reconstruction of cellular signalling networks and analysis of their properties

Jason A Papin; Tony Hunter; Bernhard O Palsson; Shankar Subramaniam

doi:10.1038/nrm1570

Reconstruction of cellular signalling networks and analysis of their properties

Nat Rev Mol Cell Biol. 2005 Feb;6(2):99-111. doi: 10.1038/nrm1570.

Authors

Jason A Papin¹, Tony Hunter, Bernhard O Palsson, Shankar Subramaniam

Affiliation

¹ Department of Bioengineering, 9500 Gilman Drive, Mail Code 0412, University of California, San Diego, La Jolla, California 92093-0412, USA.

PMID: 15654321
DOI: 10.1038/nrm1570

Abstract

The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cell Physiological Phenomena
Computational Biology / methods*
Computer Simulation
Humans
Models, Biological
Models, Molecular
Models, Theoretical
Protein Interaction Mapping / methods*
Signal Transduction*
Time Factors