Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV

Koen K A Van Rompay; Kristina Abel; Jonathan R Lawson; Raman P Singh; Kimberli A Schmidt; Thomas Evans; Patricia Earl; Danielle Harvey; Genoveffa Franchini; James Tartaglia; David Montefiori; Shilpa Hattangadi; Bernard Moss; Marta L Marthas

doi:10.1097/00126334-200502010-00002

Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV

J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):124-34. doi: 10.1097/00126334-200502010-00002.

Authors

Koen K A Van Rompay¹, Kristina Abel, Jonathan R Lawson, Raman P Singh, Kimberli A Schmidt, Thomas Evans, Patricia Earl, Danielle Harvey, Genoveffa Franchini, James Tartaglia, David Montefiori, Shilpa Hattangadi, Bernard Moss, Marta L Marthas

Affiliation

¹ California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA.

PMID: 15671796
DOI: 10.1097/00126334-200502010-00002

Abstract

An infant macaque model was developed to test pediatric vaccine candidates aimed at reducing HIV transmission through breast-feeding. Infant macaques were given multiple immunizations during the first 3 weeks of life with recombinant poxvirus vaccines expressing simian immunodeficiency virus (SIV) structural proteins Gag, Pol, and Env (ALVAC-SIV or modified vaccinia virus Ankara [MVA]-SIV). After repeated daily oral inoculations with virulent SIVmac251 at 4 weeks of age, significantly fewer ALVAC-SIV-immunized infants were infected compared with unimmunized infants. Monkeys not infected after oral challenge in infancy were rechallenged at 16 months of age or older by repeated weekly oral SIV exposure; unimmunized animals were infected after fewer SIV exposures than were animals vaccinated with ALVAC-SIV or MVA-SIV. When infected, ALVAC-SIV- and MVA-SIV-vaccinated animals also had reduced viremia compared with unimmunized animals. The results of these investigations suggest that immunization of human infants with poxvirus-based HIV vaccine candidates may offer protection against early and late HIV infection through breastfeeding.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Administration, Oral
Animals
Animals, Newborn
Breast Feeding / adverse effects
Female
Gene Products, env / immunology
HIV Infections / prevention & control
HIV Infections / transmission
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Macaca mulatta
Poxviridae / genetics
Retroviridae Proteins, Oncogenic / immunology
SAIDS Vaccines / administration & dosage*
SAIDS Vaccines / isolation & purification
Simian Acquired Immunodeficiency Syndrome / immunology
Simian Acquired Immunodeficiency Syndrome / prevention & control*
Simian Acquired Immunodeficiency Syndrome / virology
Simian Immunodeficiency Virus* / immunology
Simian Immunodeficiency Virus* / pathogenicity
Vaccines, Attenuated / administration & dosage
Vaccines, Attenuated / isolation & purification
Vaccines, Synthetic / administration & dosage
Vaccines, Synthetic / isolation & purification
Viral Fusion Proteins / immunology

Substances

Gene Products, env
Retroviridae Proteins, Oncogenic
SAIDS Vaccines
Vaccines, Attenuated
Vaccines, Synthetic
Viral Fusion Proteins
transmembrane protein, Simian immunodeficiency virus

Abstract

Publication types

MeSH terms

Substances

Grants and funding