A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity

V L Niranjan Reddy; S Malla Reddy; V Ravikanth; P Krishnaiah; T Venkateshwar Goud; T P Rao; T Siva Ram; Rajesh G Gonnade; Mohan Bhadbhade; Y Venkateswarlu

doi:10.1080/14786410410001709197

A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity

Nat Prod Res. 2005 Apr;19(3):223-30. doi: 10.1080/14786410410001709197.

Authors

V L Niranjan Reddy¹, S Malla Reddy, V Ravikanth, P Krishnaiah, T Venkateshwar Goud, T P Rao, T Siva Ram, Rajesh G Gonnade, Mohan Bhadbhade, Y Venkateswarlu

Affiliation

¹ Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.

PMID: 15702635
DOI: 10.1080/14786410410001709197

Abstract

Novel bis-andrographolide ether (1) and six known compounds andrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, 14-deoxyandrographolide, (+/-)-5-hydroxy-7,8-dimethoxyflavanone, and 5-hydroxy-7,8-dimethoxyflavone have been isolated from the aerial parts of Andrographis paniculata and their structures were established by spectral data. All the isolates were tested for the anti-HIV and cytotoxic activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Andrographis / chemistry*
Antiviral Agents / isolation & purification*
Antiviral Agents / pharmacology
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Ethers
Flavones / isolation & purification*
Flavones / pharmacology
HIV Infections / drug therapy
HIV-1 / drug effects
Humans
Microbial Sensitivity Tests

Substances

Antiviral Agents
Diterpenes
Ethers
Flavones
andrographolide