Abstract
Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system - it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer-->activator-->Mediator-->pol II-->promoter pathway. The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Humans
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Multiprotein Complexes / metabolism
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RNA Polymerase II / metabolism*
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Trans-Activators / metabolism*
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Transcription Factors / metabolism
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Transcription, Genetic*
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Transcriptional Activation*
Substances
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Fungal Proteins
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Multiprotein Complexes
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Trans-Activators
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Transcription Factors
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RNA Polymerase II