Abstract
Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Death / drug effects
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Disease Models, Animal
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Electroencephalography / methods
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Electromyography / methods
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Immunohistochemistry / methods
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Immunotoxins / toxicity*
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Neurons / pathology*
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Neurons / physiology
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Polysomnography / methods
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Rats
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Receptors, Neurokinin-1 / metabolism
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Respiratory Center / injuries
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Respiratory Center / pathology*
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Ribosome Inactivating Proteins, Type 1
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Saporins
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Sleep Apnea Syndromes / chemically induced
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Sleep Apnea Syndromes / pathology*
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Sleep Apnea Syndromes / physiopathology
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Sleep, REM / drug effects
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Sleep, REM / physiology
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Substance P / analogs & derivatives*
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Substance P / toxicity
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Time Factors
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Wakefulness / drug effects
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Wakefulness / physiology
Substances
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Immunotoxins
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Receptors, Neurokinin-1
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Ribosome Inactivating Proteins, Type 1
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substance P-saporin
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Substance P
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Saporins