Abstract
DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Chromatin / genetics
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Chromatin / metabolism
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DNA Helicases / genetics
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DNA Helicases / metabolism
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DNA Replication / physiology*
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Epigenesis, Genetic / physiology
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Feedback, Physiological / physiology
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Genes, cdc / physiology
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Humans
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Mitosis / physiology*
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Replication Origin / genetics*
Substances
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Cell Cycle Proteins
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Chromatin
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DNA Helicases