Membrane hemifusion: crossing a chasm in two leaps

Cell. 2005 Nov 4;123(3):375-82. doi: 10.1016/j.cell.2005.10.015.

Abstract

During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / physiology*
  • Exocytosis / physiology
  • Humans
  • Lipid Bilayers
  • Membrane Fusion / physiology*
  • Protein Transport / physiology
  • SNARE Proteins / physiology
  • Virus Physiological Phenomena

Substances

  • Lipid Bilayers
  • SNARE Proteins