Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases

Mol Biol Evol. 1992 Jul;9(4):678-87. doi: 10.1093/oxfordjournals.molbev.a040752.

Abstract

A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Composition*
  • Computer Simulation
  • Cytosine
  • DNA / genetics*
  • DNA, Mitochondrial / genetics
  • Drosophila / genetics*
  • Genetic Techniques
  • Guanosine
  • Mathematics
  • Models, Genetic

Substances

  • DNA, Mitochondrial
  • Guanosine
  • Cytosine
  • DNA