The telomeric PARP, tankyrases, as targets for cancer therapy

Br J Cancer. 2006 Feb 13;94(3):341-5. doi: 10.1038/sj.bjc.6602951.

Abstract

The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase 1 modulates telomerase inhibition in human cancer cells and is reviewed in this report as a potential telomere-directed anticancer target.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Mice
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Tankyrases / antagonists & inhibitors*
  • Tankyrases / metabolism*
  • Telomerase / antagonists & inhibitors
  • Telomere / metabolism

Substances

  • Enzyme Inhibitors
  • Tankyrases
  • Telomerase