Abstract
We have isolated a peptide from brains and corpora cardiaca of Locusta migratoria which is immunologically related to the diuretic hormone of Manduca sexta. We determined its structure as a 46 amino acid linear peptide with 43-50% identity to the M. sexta hormone. Moreover, we showed that the new peptide functions as a diuretic hormone in L. migratoria, stimulating urine production by Malpighian tubules and elevating levels of cAMP in tubules.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / metabolism
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Chromatography, High Pressure Liquid
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Cyclic AMP / metabolism
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Diuresis / drug effects
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Grasshoppers
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Insect Hormones / isolation & purification*
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Insect Hormones / pharmacology
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Malpighian Tubules / drug effects
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Molecular Sequence Data
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Oligopeptides / chemical synthesis
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Sequence Homology, Nucleic Acid
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Urine
Substances
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Insect Hormones
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Oligopeptides
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Cyclic AMP