Abstract
Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain / metabolism*
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Brain / physiopathology
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Genetic Predisposition to Disease / genetics
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Glutamic Acid / metabolism*
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Homer Scaffolding Proteins
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Humans
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Mental Disorders / genetics
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Mental Disorders / metabolism*
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Mental Disorders / physiopathology
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Neural Pathways / metabolism*
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Neural Pathways / physiopathology
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Polymorphism, Genetic / genetics
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Protein Isoforms / genetics
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Synaptic Transmission / genetics
Substances
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Carrier Proteins
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Homer Scaffolding Proteins
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Protein Isoforms
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Glutamic Acid