SARS-CoV, but not HCoV-NL63, utilizes cathepsins to infect cells: viral entry

Adv Exp Med Biol. 2006:581:335-8. doi: 10.1007/978-0-387-33012-9_60.

Authors

I-Chueh Huang¹, Berend Jan Bosch, Wenhui Li, Michael Farzan, Peter M Rottier, Hyeryun Choe

Affiliation

¹ Harvard Medical School, Boston, Massachusetts 02115, USA.

No abstract available

MeSH terms

Angiotensin-Converting Enzyme 2
Cathepsin L
Cathepsins / chemistry
Cathepsins / physiology*
Cell Line
Coronavirus / pathogenicity*
Cysteine Endopeptidases / chemistry
Humans
Membrane Fusion*
Membrane Glycoproteins / physiology*
Peptidyl-Dipeptidase A / physiology
Severe acute respiratory syndrome-related coronavirus / pathogenicity*
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins / chemistry
Viral Envelope Proteins / physiology*

Substances

Membrane Glycoproteins
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins
Cathepsins
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2
Cysteine Endopeptidases
CTSL protein, human
Cathepsin L