Abstract
The replication and transcription activator protein, Rta, is encoded by Orf50 in Kaposi's sarcoma-associated herpesvirus (KSHV) and other known gammaherpesviruses including Epstein-Barr virus (EBV), rhesus rhadinovirus (RRV), herpesvirus saimiri (HVS), and murine herpesvirus 68 (MHV-68). Each Rta/Orf50 homologue of each gammaherpesvirus plays a pivotal role in the initiation of viral lytic gene expression and lytic reactivation from latency. Here we discuss the Rta/Orf50 of KSHV in comparison to the Rta/Orf50s of other gammaherpesviruses in an effort to identify structural motifs, mechanisms of action, and modulating host factors.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Genes, Immediate-Early
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Herpesvirus 4, Human / genetics
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Herpesvirus 8, Human / genetics*
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Humans
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Immediate-Early Proteins / chemistry
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Immediate-Early Proteins / genetics
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Immediate-Early Proteins / physiology*
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Promoter Regions, Genetic
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Rhadinovirus / genetics
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Trans-Activators / chemistry
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Trans-Activators / genetics
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Trans-Activators / physiology*
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Transcriptional Activation
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Viral Proteins / chemistry
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Viral Proteins / genetics
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Viral Proteins / physiology*
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Virus Activation
Substances
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Immediate-Early Proteins
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Rta protein, Human herpesvirus 8
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Trans-Activators
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Viral Proteins