msHOT: modifying Hudson's ms simulator to incorporate crossover and gene conversion hotspots

Garrett Hellenthal; Matthew Stephens

doi:10.1093/bioinformatics/btl622

msHOT: modifying Hudson's ms simulator to incorporate crossover and gene conversion hotspots

Bioinformatics. 2007 Feb 15;23(4):520-1. doi: 10.1093/bioinformatics/btl622. Epub 2006 Dec 6.

Authors

Garrett Hellenthal¹, Matthew Stephens

Affiliation

¹ Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK. hellenth@stats.ox.ac.uk

PMID: 17150995
DOI: 10.1093/bioinformatics/btl622

Abstract

We have incorporated both crossover and gene conversion hotspots into an existing coalescent-based program for simulating genetic variation data for a sample of chromosomes from a population.

Availability: The source code for msHOT is available at http://home.uchicago.edu/~rhudson1, along with accompanying instructions.

MeSH terms

Algorithms
Chromosome Mapping / methods*
Crossing Over, Genetic / genetics*
Gene Conversion / genetics*
Genetic Variation / genetics*
Genetics, Population*
Models, Genetic*
Software*