Abstract
Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar Typhimurium has a key role in selectively silencing the transcription of large numbers of horizontally acquired AT-rich genes, including those that make up its major pathogenicity islands. Broadly similar conclusions have emerged from a study of H-NS binding to DNA in Escherichia coli. How do these findings affect our view of H-NS and its ability to influence bacterial evolution?
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AT Rich Sequence
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Binding Sites
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Escherichia coli / genetics*
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Escherichia coli / metabolism
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Gene Expression Regulation, Bacterial*
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Gene Silencing*
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Gene Transfer, Horizontal
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Genome, Bacterial*
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Salmonella typhimurium / genetics*
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Salmonella typhimurium / metabolism
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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H-NS protein, bacteria