Abstract
The novel macrolide cruentaren A was produced at levels up to 3.2 mg/liter by cultures of the myxobacterium Byssovorax cruenta. The new compound strongly inhibited the growth of yeasts and filamentous fungi and showed high cytotoxicity against L929 mouse fibroblast cells. A minor co-metabolite of cruentaren A, named cruentaren B, and identified as a six-membered lactone isomer of cruentaren A, showed only marginal cytotoxicity and no antifungal activity. Cruentaren A inhibited F0F1 mitochondrial ATP-hydrolysis in submitochondrial particles of yeasts and beef heart.
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / metabolism
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Antifungal Agents / pharmacology*
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Cattle
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Fermentation
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Fibroblasts
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Fungi / drug effects
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Isocoumarins / chemistry
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Isocoumarins / isolation & purification
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Isocoumarins / metabolism
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Isocoumarins / pharmacology*
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Macrolides / chemistry
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Macrolides / isolation & purification
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Macrolides / metabolism
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Macrolides / pharmacology*
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Mice
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Mitochondria / drug effects
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Mitochondria / enzymology
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Mitochondrial Proton-Translocating ATPases / antagonists & inhibitors*
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Molecular Structure
Substances
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Antifungal Agents
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Isocoumarins
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Macrolides
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cruentaren A
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cruentaren B
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Mitochondrial Proton-Translocating ATPases