The basal ganglia: an overview of circuits and function

Amy A Utter; Michele A Basso

doi:10.1016/j.neubiorev.2006.11.003

The basal ganglia: an overview of circuits and function

Neurosci Biobehav Rev. 2008;32(3):333-42. doi: 10.1016/j.neubiorev.2006.11.003. Epub 2007 Jan 2.

Authors

Amy A Utter¹, Michele A Basso

Affiliation

¹ Department of Physiology, University of Wisconsin, Madison School of Medicine and Public Health, Madison, WI 53706, USA.

PMID: 17202023
DOI: 10.1016/j.neubiorev.2006.11.003

Abstract

The technique of electrical stimulation of brain tissue-known clinically as deep brain stimulation (DBS)-is at the fore of treatment of human neurological disease. Here we provide a general overview highlighting the anatomy and circuitry of the basal ganglia (BG). We introduce common disease states associated with BG dysfunction and current hypotheses of BG function. Throughout this introductory review we direct the reader to other reviews in this special issue of Neuroscience and Biobehavioral Reviews highlighting the interaction between basic science and clinical investigation to more fully understand the BG in both health and disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Basal Ganglia / anatomy & histology*
Basal Ganglia / physiology
Basal Ganglia / physiopathology
Basal Ganglia Diseases / physiopathology*
Basal Ganglia Diseases / therapy
Deep Brain Stimulation
Electric Stimulation*
Humans
Neural Pathways / physiology*
Neural Pathways / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding