Abstract
Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Gene Silencing
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Histone-Lysine N-Methyltransferase / metabolism*
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Histones / metabolism*
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Jumonji Domain-Containing Histone Demethylases
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Lysine / metabolism*
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Oxidoreductases, O-Demethylating / metabolism*
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / enzymology*
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Saccharomyces cerevisiae Proteins / metabolism*
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Telomere / metabolism
Substances
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Histones
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Saccharomyces cerevisiae Proteins
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Oxidoreductases, O-Demethylating
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JHD2 protein, S cerevisiae
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Jumonji Domain-Containing Histone Demethylases
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Histone-Lysine N-Methyltransferase
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Lysine