Abstract
Retroviruses make a long and complex journey from outside the cell to the nucleus in the early stages of infection, and then an equally long journey back out again in the late stages of infection. Ongoing efforts are identifying an enormous array of cellular proteins that are used by the viruses in the course of their travels. These host factors are potential new targets for therapeutic intervention.
MeSH terms
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Animals
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Cell Nucleus / virology
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Cells / virology*
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Humans
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Protein Biosynthesis
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Proteins / genetics
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Proteins / physiology*
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Proviruses / physiology
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RNA, Viral / genetics
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RNA, Viral / metabolism
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Retroviridae / genetics
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Retroviridae / physiology*
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Retroviridae Proteins / biosynthesis
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Retroviridae Proteins / genetics
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Retroviridae Proteins / metabolism
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Transcription, Genetic
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Virus Integration
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Virus Internalization
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Virus Replication*
Substances
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Proteins
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RNA, Viral
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Retroviridae Proteins