Abstract
Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adenosine Triphosphate / chemistry
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Animals
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Chromatin / chemistry*
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Chromatin / metabolism
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Chromatin Assembly and Disassembly
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DNA / chemistry
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / physiology*
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Drosophila melanogaster
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Humans
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Models, Genetic
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Multigene Family
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Mutation*
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Protein Binding
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Protein Structure, Tertiary
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Saccharomyces cerevisiae Proteins / chemistry
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Saccharomyces cerevisiae Proteins / genetics*
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Saccharomyces cerevisiae Proteins / physiology*
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Transcription, Genetic
Substances
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CHD1 protein, S cerevisiae
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Chromatin
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DNA-Binding Proteins
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Saccharomyces cerevisiae Proteins
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Adenosine Triphosphate
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DNA