Physiology of tmRNA: what gets tagged and why?

Curr Opin Microbiol. 2007 Apr;10(2):169-75. doi: 10.1016/j.mib.2007.03.014. Epub 2007 Mar 26.

Abstract

Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bacteria / genetics*
  • Bacterial Physiological Phenomena
  • RNA, Bacterial / physiology*
  • RNA, Messenger / physiology
  • RNA-Binding Proteins / physiology
  • Ribosomes / physiology

Substances

  • RNA, Bacterial
  • RNA, Messenger
  • RNA-Binding Proteins
  • small protein B
  • tmRNA