Abstract
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acid Anhydride Hydrolases / chemistry*
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Binding Sites
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Bluetongue virus / chemistry*
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Crystallography, X-Ray
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Methyltransferases / chemistry*
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Protein Conformation
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RNA Caps*
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RNA Nucleotidyltransferases / chemistry*
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RNA, Viral / metabolism
Substances
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RNA Caps
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RNA, Viral
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Methyltransferases
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mRNA (guanine(N7))-methyltransferase
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mRNA (nucleoside-O(2'))-methyltransferase
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RNA Nucleotidyltransferases
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Acid Anhydride Hydrolases
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RNA triphosphatase
Associated data
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PDB/2JH8
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PDB/2JH9
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PDB/2JHA
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PDB/2JHC
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PDB/2JHP