A signal for the caspase-1 inflammasome free of TLR

Immunity. 2007 Apr;26(4):383-5. doi: 10.1016/j.immuni.2007.04.005.

Abstract

Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caspase 1 / metabolism*
  • Humans
  • Inflammation / enzymology
  • Inflammation / immunology*
  • Interleukin-1beta / metabolism*
  • Toll-Like Receptors / metabolism*

Substances

  • Interleukin-1beta
  • Toll-Like Receptors
  • Caspase 1