Abstract
We used a diffusion tensor imaging-based whole-brain tissue segmentation to characterize age-related changes in (a) whole-brain grey matter, white matter, and cerebrospinal fluid relative to intracranial volume and (b) the corresponding brain tissue microstructure using measures of diffusion tensor anisotropy and mean diffusivity. The sample, a healthy cohort of 119 right-handed males and females aged 7-68 years. Our results demonstrate that white matter and grey matter volumes and their corresponding diffusion tensor anisotropy and mean diffusivity follow nonlinear trajectories with advancing age. In contrast, cerebrospinal fluid volume increases linearly with age.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adolescent Development / physiology*
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Adult
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Aged
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Aging / physiology*
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Anisotropy
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Atrophy / pathology
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Atrophy / physiopathology
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Brain / anatomy & histology
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Brain / growth & development*
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Brain Mapping / methods*
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Cerebral Ventricles / anatomy & histology
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Cerebral Ventricles / growth & development
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Child
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Child Development / physiology*
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Cohort Studies
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Diffusion Magnetic Resonance Imaging / methods*
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Female
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Humans
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Male
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Middle Aged
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Nerve Fibers, Myelinated / physiology
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Nerve Fibers, Myelinated / ultrastructure
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Neurons / cytology
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Neurons / physiology
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Neuropil / cytology
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Neuropil / physiology
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Nonlinear Dynamics
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Subarachnoid Space / anatomy & histology
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Subarachnoid Space / growth & development