Abstract
In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane. The general Secretion route, termed Sec-pathway, catalyzes the transmembrane translocation of proteins in their unfolded conformation, whereupon they fold into their native structure at the trans-side of the membrane. The Twin-arginine translocation pathway, termed Tat-pathway, catalyses the translocation of secretory proteins in their folded state. Although the targeting signals that direct secretory proteins to these pathways show a high degree of similarity, the translocation mechanisms and translocases involved are vastly different.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphatases / physiology*
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Adenosine Triphosphate / metabolism
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism*
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Bacterial Proteins / physiology
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Carrier Proteins / physiology*
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Cell Membrane / metabolism*
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Energy Metabolism / physiology
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Escherichia coli Proteins / physiology
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Membrane Transport Proteins / physiology*
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Metabolic Networks and Pathways / physiology*
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Models, Biological
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Models, Molecular
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Protein Folding
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Protein Sorting Signals / physiology
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Protein Transport / physiology
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SEC Translocation Channels
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SecA Proteins
Substances
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Bacterial Proteins
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Carrier Proteins
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Escherichia coli Proteins
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Membrane Transport Proteins
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Protein Sorting Signals
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SEC Translocation Channels
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twin-arginine translocase complex, E coli
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Adenosine Triphosphate
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Adenosine Triphosphatases
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SecA Proteins