Abstract
Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. The receptor-binding domain of PvDBP maps to a conserved cysteine-rich region, referred to as region II (PvRII). Here, we review data on the interaction of PvRII with DARC and explore the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Protozoan / metabolism
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Antigens, Protozoan / immunology
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Antigens, Protozoan / metabolism*
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Chemokines / metabolism
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Duffy Blood-Group System / metabolism*
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Erythrocytes / metabolism
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Erythrocytes / parasitology*
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Humans
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Malaria, Vivax / metabolism
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Malaria, Vivax / prevention & control*
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Plasmodium knowlesi / metabolism
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Plasmodium vivax / physiology*
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Protozoan Proteins / immunology
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Protozoan Proteins / metabolism*
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Protozoan Vaccines
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Receptors, Cell Surface / immunology
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Receptors, Cell Surface / metabolism*
Substances
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ACKR1 protein, human
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Antibodies, Protozoan
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Antigens, Protozoan
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Chemokines
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Duffy Blood-Group System
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Duffy antigen binding protein, Plasmodium
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Protozoan Proteins
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Protozoan Vaccines
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Receptors, Cell Surface