Transient receptor potential vanilloid receptor-1 confers heat resistance to male germ cells

Sefika Canan Mizrak; Federica M F van Dissel-Emiliani

doi:10.1016/j.fertnstert.2007.10.081

Transient receptor potential vanilloid receptor-1 confers heat resistance to male germ cells

Fertil Steril. 2008 Oct;90(4):1290-3. doi: 10.1016/j.fertnstert.2007.10.081. Epub 2008 Jan 28.

Authors

Sefika Canan Mizrak¹, Federica M F van Dissel-Emiliani

Affiliation

¹ Fertility Laboratory, Center for Reproductive Medicine, Academic Medical Center, Amsterdam, The Netherlands. s.c.mizrak@amc.uva.nl

PMID: 18222434
DOI: 10.1016/j.fertnstert.2007.10.081

Abstract

Testicular hyperthermia in mice lacking transient receptor potential vanilloid receptor-1 results in a much more rapid and massive germ cell depletion from the seminiferous tubules than in wild-type animals, indicating that this receptor protects germ cells against heat stress.

MeSH terms

Animals
Cells, Cultured
Heat-Shock Response / physiology*
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Spermatozoa / cytology*
Spermatozoa / physiology*
TRPV Cation Channels / genetics
TRPV Cation Channels / metabolism*

Substances

TRPV Cation Channels
TRPV1 protein, mouse