Effect of MAP2, MAP2c, and tau on kinesin-dependent microtubule motility

S Heins; Y H Song; H Wille; E Mandelkow; E M Mandelkow

doi:10.1242/jcs.1991.supplement_14.24

Effect of MAP2, MAP2c, and tau on kinesin-dependent microtubule motility

J Cell Sci Suppl. 1991:14:121-4. doi: 10.1242/jcs.1991.supplement_14.24.

Authors

S Heins¹, Y H Song, H Wille, E Mandelkow, E M Mandelkow

Affiliation

¹ Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany.

PMID: 1832164
DOI: 10.1242/jcs.1991.supplement_14.24

Abstract

By making use of DIC video microscopy to monitor microtubule motility we have studied the effect of several MAPs (MAP2, MAP2c, tau) on microtubule-kinesin interactions and microtubule gliding. Of the three MAPs tested, MAP2 interferes most strongly with kinesin-dependent microtubule motility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphatases / physiology*
Animals
Biological Transport
Kinesins
Microtubule-Associated Proteins*
Microtubules / physiology*
Photomicrography
Swine
Videotape Recording
tau Proteins

Substances

Microtubule-Associated Proteins
tau Proteins
Adenosine Triphosphatases
Kinesins