Abstract
Recent global analyses have determined that many Drosophila and human genes have engaged polymerase molecules trapped immediately downstream of promoters. These results strongly implicate RNA polymerase II elongation control as a major regulator of differentiation and development.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Gene Expression Regulation*
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Humans
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Positive Transcriptional Elongation Factor B / metabolism
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Promoter Regions, Genetic
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Protein Biosynthesis*
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RNA Polymerase II / genetics
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RNA Polymerase II / metabolism*
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Transcription, Genetic*
Substances
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Positive Transcriptional Elongation Factor B
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RNA Polymerase II