Abstract
The development of heart failure is associated with alterations in the expression of a wide variety of structural, signaling, and metabolic proteins. One such effect is the downregulation of uncoupling proteins in the setting of heart failure. This group of proteins regulates the mitochondrial membrane potential and therefore plays a role in mitochondrial energy metabolism as well as reactive oxygen species generation by the mitochondria. This review discusses the role of uncoupling proteins in regulating oxidant stress and implications with respect to the pathogenesis of heart failure and potential treatments.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Disease Models, Animal
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Disease Progression
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Down-Regulation
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Energy Metabolism / physiology
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Female
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Gene Expression Regulation
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Heart Failure / metabolism
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Heart Failure / physiopathology*
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Humans
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Ion Channels / genetics
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Ion Channels / metabolism*
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Male
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Mitochondria / metabolism
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Mitochondrial Proteins / genetics
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Mitochondrial Proteins / metabolism*
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Oxidative Stress / physiology*
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RNA, Messenger / analysis
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Rats
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Reactive Oxygen Species / metabolism*
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Sensitivity and Specificity
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Severity of Illness Index
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Uncoupling Protein 2
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Uncoupling Protein 3
Substances
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Ion Channels
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Mitochondrial Proteins
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RNA, Messenger
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Reactive Oxygen Species
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Uncoupling Protein 2
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Uncoupling Protein 3