One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally attributed as having little, if any, antigen-presentation function. Instead, pDCs are regarded as immunomodulating cells, capable of directing the immune response through their secretion of large amounts of type I interferons. In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes.