Abstract
Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Actins / metabolism
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Cell Polarity / physiology
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Cilia / physiology*
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Dishevelled Proteins
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Embryo, Nonmammalian / metabolism
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Epithelial Cells / cytology
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Epithelial Cells / physiology*
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Phosphoproteins / metabolism*
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Rho Factor / metabolism
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Wnt Proteins / metabolism*
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Xenopus Proteins / metabolism*
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Xenopus laevis / metabolism
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beta Catenin / metabolism*
Substances
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Actins
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Adaptor Proteins, Signal Transducing
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Dishevelled Proteins
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Phosphoproteins
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Rho Factor
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Wnt Proteins
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Xenopus Proteins
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beta Catenin