Microenvironment driven invasion: a multiscale multimodel investigation

J Math Biol. 2009 Apr;58(4-5):579-624. doi: 10.1007/s00285-008-0210-2. Epub 2008 Oct 7.

Abstract

Cancer is a complex, multiscale process, in which genetic mutations occurring at a subcellular level manifest themselves as functional and morphological changes at the cellular and tissue scale. The importance of interactions between tumour cells and their microenvironment is currently of great interest in experimental as well as computational modelling. Both the immediate microenvironment (e.g. cell-cell signalling or cell-matrix interactions) and the extended microenvironment (e.g. nutrient supply or a host tissue structure) are thought to play crucial roles in both tumour progression and suppression. In this paper we focus on tumour invasion, as defined by the emergence of a fingering morphology, which has previously been shown to be dependent upon harsh microenvironmental conditions. Using three different modelling approaches at two different spatial scales we examine the impact of nutrient availability as a driving force for invasion. Specifically we investigate how cell metabolism (the intrinsic rate of nutrient consumption and cell resistance to starvation) influences the growing tumour. We also discuss how dynamical changes in genetic makeup and morphological characteristics, of the tumour population, are driven by extreme changes in nutrient supply during tumour development. The simulation results indicate that aggressive phenotypes produce tumour fingering in poor nutrient, but not rich, microenvironments. The implication of these results is that an invasive outcome appears to be co-dependent upon the evolutionary dynamics of the tumour population driven by the microenvironment.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Apoptosis
  • Biological Evolution
  • Cell Adhesion
  • Cell Movement
  • Cell Proliferation
  • Extracellular Matrix / pathology
  • Extracellular Matrix / physiology
  • Humans
  • Mathematical Concepts
  • Models, Biological*
  • Neoplasm Invasiveness / pathology*
  • Neoplasm Invasiveness / physiopathology
  • Oxygen Consumption
  • Receptors, Cell Surface / physiology

Substances

  • Receptors, Cell Surface