Abstract
A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a polyene peroxide with pronounced antifungal activity. Its structure, absolute configuration, and biological activity were determined by spectral analysis, chemical modification followed by the modified Mosher method, and growth inhibitory assays, respectively.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Acetates / chemistry
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Acetates / isolation & purification*
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Acetates / pharmacology
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Coleoptera / microbiology
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Molecular Structure
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Peroxides / chemistry
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Peroxides / isolation & purification*
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Peroxides / pharmacology
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Pinus
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Polyenes / chemistry
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Polyenes / isolation & purification*
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Polyenes / pharmacology
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Streptomyces / chemistry*
Substances
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Acetates
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Antifungal Agents
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Peroxides
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Polyenes
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mycangimycin