Abstract
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Activating Transcription Factor 4 / genetics
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Activating Transcription Factor 4 / metabolism
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Animals
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Eukaryotic Initiation Factor-2 / genetics
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Eukaryotic Initiation Factor-2 / metabolism
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Fragile X Mental Retardation Protein / genetics
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Fragile X Mental Retardation Protein / metabolism
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Gene Expression Regulation*
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Memory / physiology*
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MicroRNAs / genetics
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MicroRNAs / metabolism
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Neuronal Plasticity / physiology*
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Neurons / cytology
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Neurons / physiology
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Protein Biosynthesis*
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Protein Kinases / genetics
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Protein Kinases / metabolism
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RNA, Messenger / metabolism
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Ribosomal Protein S6 Kinases / genetics
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Ribosomal Protein S6 Kinases / metabolism
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Signal Transduction / physiology
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TOR Serine-Threonine Kinases
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mRNA Cleavage and Polyadenylation Factors / metabolism
Substances
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Carrier Proteins
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Eukaryotic Initiation Factor-2
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MicroRNAs
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RNA, Messenger
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mRNA Cleavage and Polyadenylation Factors
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Fragile X Mental Retardation Protein
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Activating Transcription Factor 4
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Protein Kinases
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Ribosomal Protein S6 Kinases
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TOR Serine-Threonine Kinases