Abstract
Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / genetics*
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Apoptosis / physiology
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Caspases / genetics
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Caspases / physiology
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Cell Proliferation
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Drosophila Proteins / genetics
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Drosophila Proteins / physiology
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Drosophila melanogaster / cytology*
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Drosophila melanogaster / embryology
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / physiology
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Female
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Genes, Insect
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Models, Genetic
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Mutation
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Oogenesis
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Signal Transduction
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Ubiquitination
Substances
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Drosophila Proteins
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dark protein, Drosophila
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Caspases