Regulation of angiogenesis by oxygen and metabolism

Peter Fraisl; Massimiliano Mazzone; Thomas Schmidt; Peter Carmeliet

doi:10.1016/j.devcel.2009.01.003

Regulation of angiogenesis by oxygen and metabolism

Dev Cell. 2009 Feb;16(2):167-79. doi: 10.1016/j.devcel.2009.01.003.

Authors

Peter Fraisl¹, Massimiliano Mazzone, Thomas Schmidt, Peter Carmeliet

Affiliation

¹ Vesalius Research Center, Leuven, Belgium.

PMID: 19217420
DOI: 10.1016/j.devcel.2009.01.003

Abstract

Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regarding the emerging crosstalk between angiogenesis and metabolism. We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / metabolism
Blood Vessels / metabolism
Cell Lineage
Endothelial Cells / metabolism
Epigenesis, Genetic
Gene Expression Regulation, Developmental*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Mice
Models, Biological
Myocytes, Smooth Muscle / metabolism
Neovascularization, Pathologic*
Oxygen / metabolism*
Signal Transduction

Substances

Basic Helix-Loop-Helix Transcription Factors
HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
endothelial PAS domain-containing protein 1
Oxygen