Pre-mRNA processing reaches back to transcription and ahead to translation

Melissa J Moore; Nick J Proudfoot

doi:10.1016/j.cell.2009.02.001

Pre-mRNA processing reaches back to transcription and ahead to translation

Cell. 2009 Feb 20;136(4):688-700. doi: 10.1016/j.cell.2009.02.001.

Authors

Melissa J Moore¹, Nick J Proudfoot

Affiliation

¹ Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. melissa.moore@umassmed.edu

PMID: 19239889
DOI: 10.1016/j.cell.2009.02.001

Abstract

The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Feedback
Gene Expression Regulation*
Humans
Protein Biosynthesis*
RNA Precursors / metabolism*
RNA Processing, Post-Transcriptional*
RNA Stability
Transcription, Genetic*

Substances

RNA Precursors

Abstract

Publication types

MeSH terms

Substances

Grants and funding