Abstract
Manipulations of activity in one retina can profoundly affect binocular connections in the visual cortex. Retinal activity is relayed to the cortex by the dorsal lateral geniculate nucleus (dLGN). We compared the qualities and amount of activity in the dLGN following monocular eyelid closure and monocular retinal inactivation in awake mice. Our findings substantially alter the interpretation of previous studies and define the afferent activity patterns that trigger cortical plasticity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology
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Anesthetics, Local
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Animals
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Brain Mapping
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Evoked Potentials, Visual / drug effects
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Evoked Potentials, Visual / physiology
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Functional Laterality
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Geniculate Bodies / physiology*
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Hypnotics and Sedatives / pharmacology
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Mice
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Neuronal Plasticity / physiology*
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Neurons / physiology*
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Pentobarbital / pharmacology
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Photic Stimulation
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Retina / physiology*
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Sensory Deprivation / physiology
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Tetrodotoxin / pharmacology
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Time Factors
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Vision, Monocular / drug effects
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Vision, Monocular / physiology
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Visual Cortex / cytology*
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Visual Cortex / physiology*
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Visual Pathways / drug effects
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Visual Pathways / physiology
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Visual Perception
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Wakefulness
Substances
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Anesthetics, Local
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Hypnotics and Sedatives
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Tetrodotoxin
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Pentobarbital