Abstract
ZMPSTE24 is an integral membrane zinc metalloprotease originally discovered in yeast as an enzyme (called Ste24p) required for maturation of the mating pheromone a-factor. Surprisingly, ZMPSTE24 has recently emerged as a key protease involved in human progeroid disorders. ZMPSTE24 has only one identified mammalian substrate, the precursor of the nuclear scaffold protein lamin A. ZMPSTE24 performs a critical endoproteolytic cleavage step that removes the hydrophobic farnesyl-modified tail of prelamin A. Failure to do so has drastic consequences for human health and longevity. Here, we discuss the discovery of the yeast and mammalian ZMPSTE24 orthologs and review the unexpected connection between ZMPSTE24 and premature aging.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging, Premature / genetics*
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Amino Acid Sequence
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Animals
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Enzyme Inhibitors / therapeutic use
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Farnesyltranstransferase / antagonists & inhibitors
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HIV Protease Inhibitors / pharmacology
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Humans
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Lamin Type A / genetics
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Lamin Type A / metabolism
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Lipoproteins / metabolism
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Metalloendopeptidases / genetics
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Metalloendopeptidases / physiology*
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Mice
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Molecular Sequence Data
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Nuclear Proteins / metabolism
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Pheromones / metabolism
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Progeria / drug therapy
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Progeria / genetics*
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Protein Precursors / metabolism
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Saccharomyces cerevisiae Proteins / metabolism
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Saccharomyces cerevisiae Proteins / physiology*
Substances
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Enzyme Inhibitors
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HIV Protease Inhibitors
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Lamin Type A
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Lipoproteins
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MFA2 protein, S cerevisiae
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Membrane Proteins
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Nuclear Proteins
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Pheromones
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Protein Precursors
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Saccharomyces cerevisiae Proteins
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prelamin A
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Farnesyltranstransferase
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Metalloendopeptidases
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STE24 protein, S cerevisiae
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ZMPSTE24 protein, human