Abstract
The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Asthma / metabolism
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HSP20 Heat-Shock Proteins / metabolism
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HSP20 Heat-Shock Proteins / physiology*
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Humans
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Hyperplasia / metabolism
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Molecular Sequence Data
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Muscle, Skeletal / metabolism
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Muscle, Smooth / metabolism
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Myocardium / metabolism
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Phosphopeptides
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Rats
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Signal Transduction
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Subarachnoid Hemorrhage / metabolism
Substances
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HSP20 Heat-Shock Proteins
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HSPB6 protein, human
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Phosphopeptides