Abstract
A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (tRNAs) by ribonucleases that are normally secreted or sequestered. Ribonuclease activation or release is an intriguing new aspect of cellular stress responses, with a potential impact on translation, apoptosis, cancer, and disease progression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Physiological Phenomena
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Cell Physiological Phenomena*
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Cells / enzymology
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Humans
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Protein Biosynthesis
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RNA, Messenger / metabolism
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RNA, Transfer / metabolism*
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Ribonucleases / metabolism
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Stress, Physiological
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Yeasts / enzymology
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Yeasts / physiology
Substances
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RNA, Messenger
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RNA, Transfer
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Ribonucleases