Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis

Cancer Lett. 2010 Mar 28;289(2):140-50. doi: 10.1016/j.canlet.2009.07.004. Epub 2009 Aug 3.

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Castleman Disease / virology*
  • Cell Transformation, Neoplastic / pathology*
  • Herpesvirus 8, Human / physiology*
  • Humans
  • Lymphoma, Primary Effusion / virology*
  • Oncogenic Viruses
  • Sarcoma, Kaposi / virology*
  • Tumor Virus Infections / virology
  • Virus Latency