Abstract
Decline in CD4 T cell function is the hallmark of aging. In this study, we compared the proportion and absolute number of inhibitory receptor expressing splenic CD4 T cells in unprimed young (2 months) and aged (20 months) C57BL/6 mice. Our results showed a predominance of PD-1, ICOS and CTLA-4 expressing conventional and regulatory CD4 T cells in aged mice. Furthermore, the expression of these molecules was localized to memory but not naïve CD4 T cell subset. Since aging is associated with decline in naïve but accumulation of hyporesponsive memory phenotype (MP) CD4 T cell, we hypothesize that inhibitory receptors can account for the senescence noted in MP subset of CD4 T cell.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Aging / immunology*
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Animals
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Antigens, CD / metabolism
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Antigens, Differentiation / metabolism
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Antigens, Differentiation, T-Lymphocyte / metabolism
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CD4-Positive T-Lymphocytes / immunology*
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CTLA-4 Antigen
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Immune Tolerance
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Immunologic Memory
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Inducible T-Cell Co-Stimulator Protein
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Mice
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Mice, Inbred C57BL
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Programmed Cell Death 1 Receptor
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Spleen / cytology
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Spleen / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation
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Antigens, Differentiation, T-Lymphocyte
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CTLA-4 Antigen
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Ctla4 protein, mouse
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Icos protein, mouse
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Inducible T-Cell Co-Stimulator Protein
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Pdcd1 protein, mouse
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Programmed Cell Death 1 Receptor