Abstract
Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism
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Animals
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / metabolism*
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Bacillus anthracis / metabolism*
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Bacillus anthracis / pathogenicity
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Bacterial Toxins / chemistry
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Bacterial Toxins / metabolism*
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Endocytosis / physiology*
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Endosomes / metabolism
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GTPase-Activating Proteins / metabolism
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Humans
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Hydrogen-Ion Concentration
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Low Density Lipoprotein Receptor-Related Protein-6
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Models, Molecular
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Protein Conformation
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Protein Subunits / metabolism*
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Receptors, LDL / metabolism
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Receptors, Peptide / chemistry
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Receptors, Peptide / metabolism*
Substances
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ARAP3 protein, human
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Adaptor Proteins, Signal Transducing
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Antigens, Bacterial
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Bacterial Toxins
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GTPase-Activating Proteins
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LRP6 protein, human
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Low Density Lipoprotein Receptor-Related Protein-6
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Protein Subunits
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Receptors, LDL
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Receptors, Peptide
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anthrax toxin
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anthrax toxin receptors