Abstract
Two recent papers published in Immunity and Cell Host & Microbe underline the great importance of B cells and of antibodies (Abs) in orchestrating crucial T helper cell type 2 (Th2) protective immune responses to gastrointestinal nematodes. The findings in animal models now raise major questions as to how B cells and Abs carry out these functions in humans. Here we discuss recent technological advances in humanizing animal models at the level of both Abs and their Fc-receptors, that might provide some answers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Helminth / immunology
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Antibodies, Monoclonal / immunology*
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Antibodies, Neutralizing / immunology*
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B-Lymphocytes / immunology*
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Humans
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Immunization, Passive
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Immunoglobulin G / immunology
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Lymphocyte Activation / immunology
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Mice
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Mice, Inbred C57BL
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Nematospiroides dubius / immunology*
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Receptors, Fc / metabolism
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Strongylida Infections / immunology*
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Strongylida Infections / parasitology
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T-Lymphocytes / immunology*
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Th2 Cells / immunology
Substances
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Antibodies, Helminth
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Antibodies, Monoclonal
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Antibodies, Neutralizing
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Immunoglobulin G
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Receptors, Fc